Valdecoxib
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| 4-(5-methyl-3-phenyl-4-isoxazolyl)-benzenesulfonamide | |
| CAS number 181695–72–7 | ATC code M01AH03 |
| Chemical formula | C16H14N2O3S |
| Molecular weight | 314.364 |
| Bioavailability | 83% |
| Metabolism | 10% |
| Elimination half-life | 8–11 hours |
| Excretion | 90% |
| Pregnancy category | In late pregnancy, valdecoxib should be avoided because it may cause premature closure of the ductus arteriosus. |
| Legal status | Recalled in US, EU, Canada & parts of Asia |
| Routes of administration | 10mg Oral |
| Information Source: | "FDA Bextra Labeling Information." FDA Bextra Labeling Information. Accessed on April 8, 2005. |
Valdecoxib is a prescription drug used in the treatment of osteoarthritis, rheumatoid arthritis, and painful menstruation and menstrual symptoms. It is classified as a nonsteroidal anti-inflammatory drug, or NSAID, and should not be taken by anyone allergic to these types of medications.
Valdecoxib is manufactured and marketed under the brand name Bextra® by G. D. Searle & Company. It is available by prescription in tablet form.
On April 7, 2005, Pfizer withdrew Bextra from the US market on recommendation by the FDA.
Table of contents |
Uses
Since its registration, Bextra was prescribed for pain associated with arthritis, menstrual discomfort, and other ailments.
On April 7, 2005 the FDA asked Pfizer, Inc. to withdraw the drug from the market because the overall risk versus benefit profile for the drug is unfavorable.
Side-effects
Reported side-effects were angina, heart attack, stroke, fatal skin reactions, and Stevens-Johnson syndrome.
Pfizer first acknowledged cardiovascular risks associated with Bextra in October of 2004. The American Heart Association soon after was presented with a report indicating patients using Bextra while recovering from heart surgery were 2.19 times more likely to suffer a stroke or heart attack than those taking placebos.
Personal injury
With the removal of the drug from the market, there is expected to be a surge in personal injury claims, many in the form of class action, to seek compensation.
External link
Categories: Non-steroidal anti-inflammatory drugs