Tata Giacobetti was a self-taught musician. He sang at the students' parties at the time when he attended scenography classes at the Fine Arts Academy in Rome. In 1940 he founded a vocal quartet called Quartetto Egie, that changed line-up and name twice, becoming Quartetto Ritmo first and then Quartetto Cetra.
Besides singing, he was the group's lyricist, while Virgilio Savona, also a member of the quartet, composed the music. They worked together for four decades and produced hundreds of songs which made up Quartetto Cetra's vast repertoire.