Phenothiazine
Phenothiazines are the largest of the 5 main classes of antipsychotic drugs. Although these drugs are generally effective, there are often serious side-effects including Parkinsonism and sedation (especially in the early stages of treatment).
There are three groups of phenothiazines, differing by their chemical structure and their pharmacological effects: -
| Group | Autonomic | Example | Sedative | Extrapyramidal side-effect |
| Aliphatic compounds | ||||
| moderate | Chlorpromazine(Thorazine, Largactil) | strong | moderate | |
| Promazine | moderate | moderate | ||
| Triflupromazine (Vesprin) | strong | moderate/strong | ||
| Levomepromazine (Nozinan) | ||||
| Piperidines | strong | Mesoridazine | strong | weak |
| Thioridazine (Mellaril) | strong | weak | ||
| Piperazines | weak | Fluphenazine | weak/moderate | strong |
| Perphenazine | weak/moderate | strong | ||
| Prochlorperazine (Stemetil) | ||||
| Trifluoperazine (Stelazine) | moderate | strong |
Categories: Antipsychotics