Exercitatio Anatomica de Motu Cordis et Sanguinis in Animalibus

Exercitatio Anatomica de Motu Cordis et Sanguinis in Animalibus, (An Anatomical Exercise on the Motion of the Heart and Blood in Animals) is physician William Harvey's most well-known work. The book was published in 1628.

He investigated the effect of ligatures on blood flow. The book also argued that blood was pumped around the body in a "double circulation", where after being returned to the heart, it is recirculated in a closed system to the lungs and back to the heart, where it is returned to the main circulation.