There are several different monoamine transporters.
- The dopamine transporter, DAT.
- The norepinephrine transporter, NET.
- The serotonin transporter, SERT.
DAT, NET and SERT are related to each other and they all consist of a structure of 12 transmembrane helices.
Modern antidepressants typically work by enhancing serotonergic or noradrenergic neurotransmission by binding to the SERT or NET, and thereby inhibiting reuptake of serotonin and/or norepinephrine and raising active levels in the synapse. Fluoxetine is a selective serotonin reuptake inhibitor and works as a SERT antagonist. Reboxetine is a norepinephrine reuptake inhibitor and works as a NET antagonist.