Cr mimetic
Caloric restriction mimetics try to mimic the effects of caloric restriction.
A CR (Caloric restriction) mimetic is a particular compound or molecule that may — if successful — enable organisms to derive many of the health and life-extending benefits noted in calorically restricted diets. If an efficacious CR mimetic is developed, it may allow an organism to feed ad libitum and (simultaneously) achieve a long lifespan. The efficacy of such compounds might, upon safe and successful testing in animal subjects, pave the way for substantial increases in human lifespan.
Candidate compounds include the following
- Resveratrol is found in red wine and grapes. Many supplement companies market inexpensive concentrates.
- metformin mimics the gene expression of CR mice, and has extended mice's maximum life spans. It is already clinically approved to treat diabetes.
- R-Lipoic Acid
- 2-deoxy-D-glucose, or 2-DG. 2-DG interferes in glycolysis, starving a cell of fuel.
- Iodoacetate
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Categories: Gerontology | Medical treatment stubs